Differin GelDifferin Gel delivers unbelievable Acne-Fighting efficacy! Adapalene is the first new ingredient in the Over The Counter acne category in over thirty years. Differin Gel stops acne by tackling 2X as many sources of acne as the current leading ingredients. Differin Gel works completely differently by engaging at the molecular (DNA) level. In a clinical study, Differin Gel users saw a 55% reduction in acne after only 2 months of use! This increased to an 80% reduction in acne after 12 months. Differin Gel is the first Retinoid available without a prescription. Look for Differin Gel in the Skin Care Aisle.